Research

Publication List

This is a list of the main research papers published in academic journals as our research activity.

2018

Difference in morphology and interactome profiles between orthotopic and subcutaneous gastric cancer xenograft models.
Nakano K, Nishizawa T, Komura D, Fujii E, Monnai M, Kato A, Funahashi SI, Ishikawa S, Suzuki M.
J Toxicol Pathol. 2018 Oct;31(4):293-300. doi: 10.1293/tox.2018-0020.
Generation of an anti-desmoglein 3 antibody without pathogenic activity of pemphigus vulgaris for therapeutic application to squamous cell carcinoma.
Funahashi SI, Kawai S, Fujii E, Taniguchi K, Nakano K, Ishikawa S, Aburatani H, Suzuki M.
J Biochem. 2018 Sep 18. doi: 10.1093/jb/mvy074.
PAXgene-fixed paraffin-embedded sample is applicable to laser capture microdissection with well-balanced RNA quality and tissue morphology.
Yamazaki M, Yabuki N, Suzuki Y, Ito M, Ikeda A, Natori O, Suzuki M, Kato A.
J Toxicol Pathol. 2018 Jul;31(3):213-220. doi: 10.1293/tox.2017-0049.
DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.
Nishizawa T, Nakano K, Harada A, Kakiuchi M, Funahashi SI, Suzuki M, Ishikawa S, Aburatani H.
Oncotarget. 2018 May 1;9(33):23198-23207. doi: 10.18632/oncotarget.25269.
A simple method for histopathological evaluation of organoids.
Fujii E, Yamazaki M, Kawai S, Ohtani Y, Watanabe T, Kato A, Suzuki M.
J Toxicol Pathol. 2018 Jan;31(1):81-85. doi: 10.1293/tox.2017-0060. .

2017

Generation and characterization of monoclonal antibodies against human LGR6.
Funahashi SI, Suzuki Y, Nakano K, Kawai S, Suzuki M.
J Biochem. 2017 Apr 1;161(4):361-368. doi: 10.1093/jb/mvw077.

2015

Intensive Immunofluorescence Staining Methods for Low Expression Protein: Detection of Intestinal Stem Cell Marker LGR5.
Yamazaki M, Kato A, Zaitsu Y, Watanabe T, Iimori M, Funahashi S, Kitao H, Saeki H, Oki E, Suzuki M.
Acta Histochem Cytochem. 2015 Oct 29;48(5):159-64. doi: 10.1267/ahc.15019.

2014

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.
Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S.
Nat Genet. 2014 Jun;46(6):583-7. doi: 10.1038/ng.2984.

2013

Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors.
Harada T, Ozaki S, Oda A, Tsuji D, Ikegame A, Iwasa M, Udaka K, Fujii S, Nakamura S, Miki H, Kagawa K, Kuroda Y, Kawai S, Itoh K, Yamada-Okabe H, Matsumoto T, Abe M.
PLoS One. 2013 Dec 26;8(12):e83905. doi: 10.1371/journal.pone.0083905.

2012

LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.
Kobayashi S, Yamada-Okabe H, Suzuki M, Natori O, Kato A, Matsubara K, Jau Chen Y, Yamazaki M, Funahashi S, Yoshida K, Hashimoto E, Watanabe Y, Mutoh H, Ashihara M, Kato C, Watanabe T, Yoshikubo T, Tamaoki N, Ochiya T, Kuroda M, Levine AJ, Yamazaki T.
Stem Cells. 2012 Dec;30(12):2631-44. doi: 10.1002/stem.1257.
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